Several groups in the department of psychiatry at Yale have a strong commitment to working together across disciplines to understand how nicotine and tobacco addiction can be prevented and treated. Currently, this highly collaborative group is focused on regulation of tobacco and vaping products that deliver nicotine. These projects focus on uptake of nicotine use in adolescents, the constituents of vape liquids and the role of flavors in promoting and maintaining use of nicotine-containing products. The Picciotto Lab contribution to this Center is focused on how oral rewards can act as conditioned reinforcers that promote nicotine intake and seeking using mouse models of cue-induced reinforcement modulated by neural pathways involved in reward and reinforcement.